Leveraging on the expertise of the Centre for Applied Physics and Radiation Technologies (CAPRT) from School of Engineering and Technology (SET), on novel low dose dosimetry, Sunway University made an attractive proposal that interested Cambridge University to collaborate on prospective positive effects of low dose radiation. The research embarks on low dose radiation hormesis of normal and cancer tissues, and we predict that there will be great potential for therapeutic applications.
These experiments use a state-of-the-art 3D primary system of trypsin-free, long-term cell culture developed by the Gurdon Institute, University of Cambridge. These 3-D cultures are meant to resemble the architecture, markers and characteristics of cancer (Nasopharyngeal Carcinoma) and normal skin explants. Studies include proliferation, differentiation, and cellular variability when exposed to different low doses of radiation. The research includes unravelling and understanding the alterations in molecular, genetic and proteomic profiles that are little known till to date.
The Sunway University team are Prof Peh Suat Cheng (Principal Investigator) from School of Medical and Life Sciences (SMLS) and Prof David Bradley (Head of CAPRT, SET), Dr Ronald Teow Sin Yeang (Department of Medical Sciences, SMLS) and Dr Chew Ming Tsuey (CAPRT, SET); Cambridge U team members comprises of Dr David Fernandez-Antoran, Gurdon Institute, CRUK-RadNET and Dr Alex Samoshkin from Translational Technology; SMC team members are Dr Koay Cheng Eng (ENT specialist), Dr Margaret Leow (Plastic and Reconstructive surgeon), Dr Heng Siew Ping and Ms Yong Jie See (Medical Physicist).